Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block

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Epidurally administered mepivacaine delays recovery of train-of-four ratio from vecuronium-induced neuromuscular block.

BACKGROUND The aim of this study was to examine the efficacy of epidurally administered mepivacaine on recovery from vecuronium-induced neuromuscular block. METHODS Eighty patients were randomly assigned to one of two study groups. They were either given epidurally a bolus of 0.15 ml kg(-1) of mepivacaine 2%, followed by repetitive injections of 0.1 ml kg(-1) h(-1) throughout the study, or we...

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Accelerated recovery from combined atracurium-vecuronium neuromuscular block.

Patients given combinations of non-depolarizing neuromuscular blocking drugs have been reported to recover from neuromuscular block more rapidly than patients given a single drug. This study was designed to assess if this phenomenon occurred with the combination of atracurium and vecuronium. During nitrous oxide-fentanyl anaesthesia, 30 adult patients were allocated randomly to receive atracuri...

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Effect of tetanic stimulation on subsequent train-of-four responses at various levels of vecuronium-induced neuromuscular block.

Tetanic stimulation influences subsequent neuromuscular responses. In addition, the tetanus-induced changes in neuromuscular responses differ according to the level of neuromuscular block at which tetanic stimulation is delivered. We studied the tetanus-induced effect on subsequent train-of-four (TOF) responses at various levels of vecuronium-induced neuromuscular block in 45 anaesthetized pati...

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Comparison of visual and measured train-of-four recovery after vecuronium-induced neuromuscular blockade using two anaesthetic techniques.

This study evaluated train-of-four recovery after the administration of vecuronium, comparing measured with visually observed responses. Responses to supramaximal stimuli of the ulnar nerves were measured by a force transducer, and compared with visually observed movements of the contralateral thumb. For the 10 patients anaesthetized with nitrous oxide and enflurane, the second, third and fourt...

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Reappearance of the train-of-four after neuromuscular blockade induced with tubocurarine, vecuronium or atracurium.

The characteristics of train-of-four recovery after atracurium or vecuronium were studied, under enflurane anaesthesia, and compared with those associated with tubocurarine-induced blockade. Ten patients each received vecuronium 0.1 mg kg-1, atracurium 0.5 mg kg-1 or tubocurarine 0.5 mg kg-1. Neuromuscular blockade was calculated as the percent depression of the first twitch, and was determined...

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ژورنال

عنوان ژورنال: British Journal of Anaesthesia

سال: 2007

ISSN: 0007-0912

DOI: 10.1093/bja/aem253